Awards
- 2001 Childhelp's Woman of the World Award which recognizes outstanding contributions by women who have bettered children's lives and humankind, in general.
- 2000 Planned Parenthood Federation of America Margaret Sanger Award. Named after the founder of Planned Parenthood, the PPFA Margaret Sanger Award is the organization's highest honor.
- Academy Awards
- 1986 Best Actress Peggy Sue Got Married Nominated
- Golden Globe
- 1989 Best Actress (Musical or Comedy) The War of the Roses (1989) Nominated
- 1986 Best Actress (Musical or Comedy) Peggy Sue Got Married (1986) Nominated
- 1985 Best Actress (Musical or Comedy) Prizzi's Honor (1985) Win
- 1984 Best Actress - Musical or Comedy Romancing the Stone (1984) Win
- 1981 New Star of the Year Body Heat (1981) Nominated
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L.A. Film Critics Association
- 1984 Best Actress Crimes of Passion (1984) Win
- 1984 Best Actress Romancing the Stone (1984) Win
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National Board of Review
- 1986 Best Actress Peggy Sue Got Married (1986) Win
- New York Film Critics Circle
- 1985 Best Actress Peggy Sue Got Married (1986) Nominated
